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Synthetic Access to Persulfuranyl Scaffolds via Direct and Indirect Methods
Yi Yang1, Lulu Han1, Liza Brettnacher1
1CNRS, Universite Claude Bernard Lyon 1, CNES, Ariane Group, LHCEP, F-69622 Villeurbanne, France.
Chemical Reviews
|July 3, 2025
Summary
Pentafluorosulfanylation (SF5) chemistry is advancing rapidly, offering unique properties for pharmaceuticals and materials. New methods enable efficient SF5 group incorporation, driving innovation in drug discovery and functional materials.
Area of Science:
- Synthetic Chemistry
- Medicinal Chemistry
- Materials Science
Background:
- The pentafluorosulfanyl (SF5) group offers unique electronic and lipophilic properties.
- SF5 is recognized as a bioisostere for -CF3 and tert-butyl groups.
- It has significant interest in pharmaceuticals, agrochemicals, and materials science.
Purpose of the Study:
- To review recent advancements in pentafluorosulfanylation methods.
- To highlight emerging applications of the SF5 group.
- To discuss the future potential of SF5 chemistry.
Main Methods:
- Review of recent literature on SF5 chemistry.
- Analysis of innovative synthetic approaches for SF5 incorporation.
- Exploration of diverse molecular frameworks containing the SF5 group.
Main Results:
- Development of novel synthetic strategies for efficient SF5 group introduction.
- Demonstration of SF5 group utility in various molecular structures.
- Identification of key advancements in SF5 chemistry.
Conclusions:
- Pentafluorosulfanylation is a valuable and evolving strategy in modern chemistry.
- The unique properties of SF5 drive innovation in drug discovery and materials science.
- Continued research in SF5 chemistry promises further breakthroughs.
