Related Experiment Video
Updated: Jun 19, 2026
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
The modified HALP score is associated with short-term mortality in critically ill patients with sepsis - A cohort
Lanzhi Lin1, Huifang Huang1, Meiying Wu1
1Intensive Care Unit, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China.
Introduction:
To systematically appraise the prognostic predictive value of the modified HALP (m-HALP) score in critically ill septic patients.
Methodology:
The m-HALP scores were computed for septic patients within the initial 24 hours of admission to the intensive care unit (ICU) utilizing data from the MIMIC-IV database. The association between the m-HALP score and 30-day mortality was evaluated using restricted cubic splines and Cox regression. Kaplan-Meier (K-M) analysis was employed to estimate survival differences. Logistic regression was conducted using data from the eICU database to validate the findings. Receiver operator characteristic (ROC) curves were generated to assess predictive value.
Results:
The m-HALP score exhibited an L-shaped association with 30-day mortality upon adjustment for multiple variables (HR: 0.84, 95% CI: 0.74-0.96). K-M curves revealed a favorable survival outcome in patients with high m-HALP scores (p < 0.001). In the validation cohort, the m-HALP score proved to be an independent factor influencing in-hospital mortality. The ROC curves suggested that the m-HALP score had a better predictive value for short-term sepsis mortality than the HALP and qSOFA score.
Conclusions:
The m-HALP score demonstrated a noteworthy correlation with short-term mortality of septic patients, making it a potentially promising biomarker of prognostic relevance.
Insights
The modified HALP (m-HALP) score shows strong prognostic value for critically ill septic patients, predicting short-term mortality effectively. This sepsis biomarker offers a promising tool for assessing patient outcomes in intensive care units.
Area of Science:
- Critical Care Medicine
- Biomarker Discovery
- Prognostic Modeling
Background:
- Sepsis poses a significant threat to critically ill patients.
- Accurate prognostic tools are crucial for timely intervention.
- The prognostic value of the modified HALP (m-HALP) score in sepsis requires systematic evaluation.
Purpose of the Study:
- To assess the prognostic predictive value of the m-HALP score in critically ill septic patients.
- To evaluate the association between m-HALP scores and 30-day mortality.
- To compare the predictive performance of m-HALP with existing scores.
Main Methods:
- Utilized data from the MIMIC-IV database for score computation and survival analysis (Cox regression, K-M curves).
- Employed restricted cubic splines to model the association with mortality.
- Validated findings using logistic regression and ROC curves from the eICU database.
Main Results:
- The m-HALP score demonstrated an L-shaped association with 30-day mortality (HR: 0.84).
- Higher m-HALP scores correlated with favorable survival outcomes (p < 0.001).
- m-HALP showed superior predictive value for short-term sepsis mortality compared to HALP and qSOFA scores.
Conclusions:
- The m-HALP score is a significant predictor of short-term mortality in septic patients.
- m-HALP exhibits promising prognostic relevance as a sepsis biomarker.
- This score can aid in risk stratification and clinical decision-making for sepsis management.
More Related Videos
04:01Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
Published on: June 14, 2024
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
