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Updated: Sep 17, 2025
14:14
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
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Gender-based outcomes following surgical aortic valve replacement: a multicentre propensity score matching analysis†
Ruggero De Paulis1, Farhad Bakhtiary2, Ali El-Sayed Ahmad2
1Department of Cardiac Surgery, European Hospital, Rome, Italy.
Summary
Surgical aortic valve replacement (SAVR) outcomes were similar between genders over three years. Females showed different left ventricular (LV) regression patterns, and quality-of-life (QoL) improvements varied despite higher initial surgical risk.
Area of Science:
- Cardiovascular Surgery
- Clinical Outcomes Research
- Gender-Based Medicine
Background:
- Investigating gender disparities in cardiovascular procedures is crucial for personalized treatment.
- Surgical aortic valve replacement (SAVR) is a common intervention for aortic valve disease.
Purpose of the Study:
- To compare three-year clinical outcomes, left ventricular (LV) regression, and quality-of-life (QoL) after SAVR between genders.
- To assess the impact of propensity score matching (PSM) on gender-based outcome analysis.
Main Methods:
- A prospective multicentre study combined data from two registries (INDURE and IMPACT).
- Propensity score matching (PSM) was used to create comparable cohorts of male and female patients undergoing SAVR.
- Outcomes, LV regression, and QoL were assessed up to three years post-surgery.
Main Results:
- Females had higher baseline surgical risk scores (EuroSCORE II, STS) and were more often in advanced NYHA/CCS classes.
- Post-SAVR clinical outcomes were similar between genders at three years.
- Significant differences in LV regression were observed, with females showing altered patterns potentially influenced by hypertension; QoL improvements also differed by gender.
Conclusions:
- Despite higher baseline risk, three-year outcomes after SAVR are comparable between genders.
- Significant improvements in functional status were observed in both genders.
- Differential QoL improvements and LV regression patterns warrant further investigation for gender-specific management strategies.
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