Related Experiment Video
Updated: Sep 17, 2025
09:10
Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
Published on: February 22, 2020
8.8K
Biopsychosocial prognostic indicators in Functional Neurological Disorder: A systematic review
Edwina R Sekine1, Richard A Kanaan2, Janine McMillan3
1School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria 3004, Australia.
Journal of Psychosomatic Research
|July 3, 2025
Summary
Workforce participation is key for better health outcomes in Functional Neurological Disorder (FND). Other factors like psychiatric history and somatization negatively impact recovery, while systemic issues require more research.
Area of Science:
- Neurology
- Psychiatry
- Rehabilitation Medicine
Background:
- Functional Neurological Disorder (FND) can cause significant disability.
- Biopsychosocial and contextual factors influencing FND outcomes require further clarification.
Purpose of the Study:
- To review existing evidence on biopsychosocial and contextual factors predicting prognosis in adults with FND.
- To identify prognostic indicators relevant to FND recovery.
Main Methods:
- Systematic review of studies involving adults diagnosed with FND.
- Quality assessment using Joanna Briggs Institute checklist for cohort studies.
- Best-evidence synthesis applied to analyze quantity and consistency of findings, mapped to ICF framework.
Main Results:
- Thirty studies (2309 participants) met inclusion criteria; 10 high and 17 medium quality.
- Psychological factors like psychiatric history, somatization, and alexithymia correlated with poorer outcomes.
- Workforce participation showed strong association with better FND outcomes; age, seizure frequency, and illness duration were unrelated.
Conclusions:
- Workforce participation is a significant positive prognostic indicator for FND recovery.
- Changes in seizure frequency may not reflect improvements in life role participation.
- Limited research exists on systemic contextual factors, highlighting a need for more investigation.
