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Causal association between chronic obstructive pulmonary disease and brain cortical structure: A Mendelian
Hai-Qiang Wang1, Yong-Keng Feng2, Xue-Bing Hu1
1Department of Pneumology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Journal of Affective Disorders
|July 3, 2025
Summary
Chronic obstructive pulmonary disease (COPD) and lung function causally impact brain cortical structure. This study reveals a significant lung-brain axis, affecting brain surface area and thickness.
Area of Science:
- Neuroscience
- Pulmonology
- Genetics
Background:
- Observational studies suggest a link between COPD and brain cortical changes.
- Causality between COPD, lung function, and brain structure remains unclear.
Purpose of the Study:
- To determine the causal effect of COPD and lung function on brain cortical surface area (SA) and thickness (TH).
Main Methods:
- Mendelian randomization (MR) analysis using GWAS data from European ancestry.
- Inverse variance weighted (IVW) method as primary analysis.
- Sensitivity analyses to ensure result robustness.
Main Results:
- Global brain cortical SA positively correlated with forced vital capacity (FVC).
- Regional analysis showed FVC positively correlated with medial orbitofrontal and middle temporal SA.
- Forced expiratory volume in one second (FEV1) negatively correlated with frontal pole SA.
Conclusions:
- COPD and lung function significantly influence brain cortical structure.
- Evidence supports the existence of a lung-brain axis.
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