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Published on: July 7, 2023
The Role of m6A-RNA Methylation in the Development, Progression, and Treatment Response of Bladder Cancer
Tatiana Sinyagovskaya1, Yuliya Li2, Natalya Vinchevskaya-Khmelnitskaya2
1Laboratory of Genetic Technologies, Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, I. M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia. tsv.relentless@gmail.com.
Abstract:
Bladder cancer (BCa) remains a significant clinical challenge because of high recurrence rates and variable response to immunotherapy and chemotherapy. Recent studies have highlighted the role of N6-methyladenosine (m6A) modification in RNA in the regulation of various cellular processes, including tumor progression and drug resistance. The review examines the impact of m6A methylation on BCa pathogenesis, with a particular special focus on the role of m6A pathway factors and m6A-modified RNAs in tumorigenesis, proliferation, invasion, and migration of cancer cells. The mechanisms of m6A-mediated chemotherapy resistance in BCa cells are discussed, including single nucleotide polymorphisms in m6A-associated patterns. Significant advances in the high-throughput analysis of m6A methylation have enabled development of novel m6A-based biomarkers for the risk assessment, early diagnostics, and prediction of relapse and treatment response in BCa. The review outlines the prospects of the m6A-based molecular diagnostics in BCa.
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