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Updated: Sep 17, 2025

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Sickle Cell Disease.

Lauren V Ready1, Mary Carroll Lee2, John C Perkins3

  • 1Department of Emergency Medicine, Oregon Health Sciences University, Portland, OR, USA.

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|July 3, 2025
PubMed
Summary
This summary is machine-generated.

Emergency providers must aggressively manage sickle cell disease (SCD) pain while ruling out critical conditions like acute chest syndrome (ACS) and sepsis. Compassionate care is essential to avoid patient stigma.

Keywords:
Acute chest syndromeAcute pain episodeQuality of lifeSickle cell diseaseSplenic sequestrationStigmaVaso-occlusive crisis

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Area of Science:

  • Emergency medicine
  • Hematology
  • Patient care

Background:

  • Sickle cell disease (SCD) significantly impacts quality of life, causing early mortality and chronic pain despite treatment advances.
  • Emergency providers (EPs) face a dual obligation in managing SCD patients.

Purpose of the Study:

  • To outline the critical responsibilities of EPs in treating patients with SCD.
  • To emphasize the need for objective pain management and concurrent pathology assessment.
  • To highlight the importance of compassionate care in SCD patient management.

Main Methods:

  • This study is a review of current emergency care protocols and best practices for sickle cell disease.
  • It synthesizes information on pain management, differential diagnoses, and patient-centered communication.

Main Results:

  • EPs must objectively manage acute pain episodes in SCD patients.
  • Concurrent, potentially life-threatening conditions such as acute chest syndrome (ACS), pulmonary embolism, sepsis, and splenic sequestration must be considered.
  • Compassionate care is crucial to mitigate stigma associated with SCD.

Conclusions:

  • Effective emergency care for SCD requires a balanced approach, addressing acute pain, identifying serious comorbidities, and providing empathetic support.
  • Prioritizing these aspects can improve patient outcomes and quality of life.