Whole-Body Magnetic Resonance Neurography-Technique, Current Perspectives, and Future Directions

Whole-body magnetic resonance neurography (WBMRN) is a radiation-free imaging modality enabling comprehensive evaluation of the peripheral nervous system from the skull base to the knee. Using advanced sequences like isotropic high-resolution 3-dimensional short-tau inversion recovery and diffusion tensor imaging, WBMRN provides high-resolution visualization of nerve anatomy and pathology, offering insights into structural and microstructural abnormalities. It aids in diagnosing and monitoring conditions such as Charcot-Marie-Tooth disease, neurofibromatosis, and chronic inflammatory demyelinating polyneuropathy. This article outlines the imaging approaches used widely for whole-body MR imaging, and discusses indications, imaging differences, and role of WBMRN for evaluation of various neuropathic disease conditions.