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Updated: Sep 17, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

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Viral associations with hematologic cancers

Mark Stasiewicz1, Tomasz M Karpiński2

  • 1Department of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, 1701 W Charleston Blvd Suite 250, Las Vegas, NV, 89102, USA.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|July 3, 2025
PubMed

Insights

Viruses are a major cause of hematologic malignancies (HMs). This review details key viruses linked to HMs, their mechanisms, and management strategies for clinicians.

Area of Science:

  • Oncology
  • Virology
  • Hematology

Background:

  • Hematologic malignancies (HMs) represent a significant global health burden, with over one million new cases in 2020.
  • Infectious agents, particularly viruses, are recognized as significant contributors to oncogenesis in hematologic cancers.
  • Understanding viral associations is crucial for managing HMs and preventing complications.

Purpose of the Study:

  • To review the current understanding of viral associations with hematologic malignancies.
  • To identify key viruses implicated in HM development and their oncogenic mechanisms.
  • To provide an overview of current management principles for virus-associated HMs.

Main Methods:

  • A comprehensive literature search of the PubMed database was conducted.
  • The review focused on identifying evidence linking specific viruses to hematologic malignancies.
  • Information on oncogenic mechanisms and clinical management was synthesized.

Main Results:

  • Epstein-Barr virus, human immunodeficiency virus, human T-lymphotropic virus, hepatitis C virus, and Kaposi sarcoma herpesvirus show strong evidence of association with HMs.
  • Reactivation of latent hepatitis B virus is a concern during HM treatment regimens.
  • Mechanisms of viral oncogenesis and current management strategies are summarized.

Conclusions:

  • Viruses play a critical role in the etiology of many hematologic malignancies.
  • Clinicians can utilize this information to determine malignancy etiology and implement preventive strategies.
  • Effective management requires addressing both the malignancy and the associated viral factors.

Keywords:
InfectionOncologyTreatmentVirology

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