Related Experiment Video

Updated: Sep 17, 2025

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis
07:38

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis

Published on: November 3, 2017

8.6K

The Aorta-Gonad-Mesonephros (AGM): A Crossroads Between Hematopoiesis and Angiogenesis. A Historical Note

Domenico Ribatti1

  • 1Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy.

Clinical Anatomy (New York, N.Y.)
|July 4, 2025
PubMed

Insights

The aorta-gonad-mesonephros (AGM) region is crucial for embryonic development, acting as a key site where hematopoietic stem cells emerge. This area bridges the development of endothelial and blood cells.

Area of Science:

  • Developmental Biology
  • Hematopoiesis
  • Embryology

Background:

  • The aorta-gonad-mesonephros (AGM) is an embryonic mesodermal region.
  • It develops from the para-aortic splanchnopleura in various species, including humans.
  • The AGM region contains the dorsal aorta, genital ridges, and mesonephros.

Purpose of the Study:

  • To highlight the critical role of the AGM region in the development of the hematopoietic system.
  • To emphasize the AGM's position at the intersection of endothelial and hematopoietic cell development.

Main Methods:

  • Historical review and analysis of existing literature.
  • Comparative embryological studies across species (chick, mouse, human).

Main Results:

  • The AGM region is a fundamental site for early hematopoietic stem cell development.
  • It serves as a crucial developmental crossroads between endothelial and hematopoietic lineages.
  • The anatomical location of the AGM, between the notochord and somatic mesoderm, is significant.

Conclusions:

  • The aorta-gonad-mesonephros (AGM) region plays a pivotal role in establishing the hematopoietic system during embryonic development.
  • Understanding the AGM's function is key to comprehending the origins of blood cells and their relationship with vascular development.
Keywords:
AGMangiogenesisendotheliumhematopoiesis

More Related Videos

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

8.6K
Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation09:12

Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation

Published on: July 28, 2023

1.7K

Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
794
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.9K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
Abdominal Aorta01:25

Abdominal Aorta

Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
1.2K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.8K
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.7K