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Advances in Miniaturized Bioreactors: Bridging Biotechnology and Tissue Engineering for Enhanced Drug Development.

Mikis R Saridis1, Alla B Salmina1,2, Sofia A Korsakova1

  • 1Centre for Soft Matter and Physics of Fluids, Bauman Moscow State Technical University, Moscow, Russia.

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Summary

This review covers micro-scale bioreactors, detailing their designs and benefits for drug development, biotechnology, and tissue engineering applications.

Keywords:
bioreactorsbiotechnologydrug developmentorganoidsorgan‐on‐a‐chiptissue engineering

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Area of Science:

  • Biotechnology and Biomedical Engineering
  • Cellular and Tissue Engineering

Background:

  • Micro-scale bioreactors are increasingly vital tools in modern biological research and development.
  • Their miniaturized format offers unique advantages over traditional large-scale systems.

Purpose of the Study:

  • To provide a comprehensive overview of recent advancements in micro-scale bioreactor technology.
  • To analyze the structural designs, inherent limitations, and key benefits of these systems.
  • To highlight their applications in drug development, advanced biotechnology, and tissue engineering.

Main Methods:

  • Literature review of recent scientific publications and patents.
  • Analysis of structural designs, operational parameters, and performance metrics.
  • Comparative assessment of micro-bioreactor capabilities against conventional systems.

Main Results:

  • Identification of diverse structural designs, including microfluidic chips and packed-bed microreactors.
  • Characterization of benefits such as enhanced mass transfer, precise control, and reduced reagent consumption.
  • Discussion of limitations including scalability challenges and potential clogging issues.

Conclusions:

  • Micro-scale bioreactors represent a significant technological leap with broad applicability.
  • Continued innovation in design and materials will further unlock their potential in various life science fields.
  • These systems are poised to accelerate progress in drug discovery, bioprocessing, and regenerative medicine.