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Published on: August 7, 2017
Pediatric Asthma Control: A Focus on Vitamin D Serum Levels in Moroccan Children
Boutaina Elgharbaoui1,2,3, Zhor Zeghari4, Housna Arrouchi1
1Medical Biotechnology Laboratory (MedBiotech), Faculty of Medecine and Pharmacy of Rabat, Mohammed V University in Rabat, Rabat, Morocco.
Insights
This study found no significant link between vitamin D levels and asthma control in 100 Moroccan children. Despite high vitamin D deficiency, serum vitamin D did not impact asthma management outcomes.
Area of Science:
- Pediatric Pulmonology
- Nutritional Science
- Clinical Research
Background:
- Asthma is a common chronic respiratory disease in children.
- Vitamin D deficiency is prevalent globally, particularly in certain populations.
- The role of vitamin D in asthma pathophysiology and control remains an area of active investigation.
Purpose of the Study:
- To investigate the association between serum vitamin D levels and asthma control in pediatric patients.
- To determine if vitamin D status influences the effectiveness of asthma management in children.
Main Methods:
- A cohort of 100 Moroccan children aged 2-16 years with asthma was recruited.
- Serum vitamin D levels were quantified using Liquid Chromatography-Tandem Mass Spectrometry (LC/MS-MS).
- Asthma control was assessed using the Global Initiative for Asthma (GINA) guidelines and the Childhood Asthma Control Test (C-ACT).
Main Results:
- A high prevalence of vitamin D deficiency was observed among the study participants.
- No statistically significant correlation was identified between serum vitamin D levels and the degree of asthma control.
- Multivariate analysis, controlling for age, body mass index (BMI), and sex, also revealed no significant association (OR = 1.02; 95% CI: 0.90-1.16, P = .72).
Conclusions:
- Children with asthma exhibit a high incidence of vitamin D deficiency.
- Current findings suggest that vitamin D levels may not be a significant determinant of asthma control in this pediatric cohort.
- Further research is warranted to fully elucidate the complex relationship between vitamin D and pediatric asthma.
Objective:
This study investigates the relationship between vitamin D levels and asthma control in children.
Methods:
A total of 100 Moroccan children (2-16 years) with asthma were assessed for serum vitamin D levels using LC/MS-MS. Asthma control was evaluated according to the GINA guidelines and the C-ACT Test.
Results:
Among the participants, 69% had well-controlled asthma, while 31% exhibited partially controlled or uncontrolled asthma. Despite a high prevalence of vitamin D deficiency, no significant correlation was found between vitamin D levels and asthma control. Multivariate analysis, adjusting for age, BMI, and sex, confirmed that there was no significant association between vitamin D levels and asthma control (OR = 1.02; 95% CI: 0.90-1.16, P = .72).
Conclusions:
Children with asthma have a high incidence of vitamin D deficiency. However, the results are not consistently in favor of a correlation between vitamin D levels and the level of asthma control.
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