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Updated: Sep 17, 2025
Experimental Model to Evaluate Resolution of Pneumonia
Published on: February 17, 2023
Time to Clinical Stability Among Pediatric Patients With Severe Pneumonia: Southwest Ethiopia: Prospective Follow-Up
Belete Fenta Kebede1, Yalemtsehay Dagnaw Genie1, Tsegaw Biyazin Tesfa2
1Debre Markos University, Ethiopia.
Insights
Pediatric patients with severe pneumonia in Ethiopia achieved clinical stability in a median of 5 days. Lower oxygen saturation was linked to longer recovery times, highlighting the need for improved interventions.
Area of Science:
- Pediatric Medicine
- Infectious Diseases
- Public Health
Background:
- Clinical stability is an early indicator in pneumonia patients.
- Severe pneumonia poses a significant health risk to children.
Purpose of the Study:
- To determine the time to clinical stability in pediatric patients with severe pneumonia in Southwest Ethiopia.
- To identify factors influencing the time to clinical stability.
Main Methods:
- Prospective follow-up study of 422 pediatric patients.
- Data collected from June to November 2022.
- Kaplan-Meier survival estimate and Cox regression analysis used.
Main Results:
- Median time to clinical stability was 5 days.
- 86.97% of patients achieved clinical stability.
- Lower oxygen saturation correlated with longer time to stability.
Conclusions:
- Most pediatric patients with severe pneumonia achieved clinical stability within 5 days.
- Further research with larger sample sizes is recommended to identify predictors of delayed stability.
- Stakeholders should focus on reducing the time to clinical stability.
Background:
Although clinical stability recognition was considered an early outcome in patients with pneumonia. Therefore, this study aimed to determine the time to clinical stability among pediatric patients with severe pneumonia in Southwest Ethiopia.
Methods:
A prospective follow-up study was conducted with 422 pediatric patients from June to November 2022 at a public hospitals. Data were analyzed using Epi-data and STATA, with the Kaplan-Meier survival estimate and Cox regression to assess time to stability and predictors. The proportional hazard model and Kaplan-Meier survival estimate graph were used to determine the time to clinical stability. Bivariate and multivariable Cox regression analysis were used to determine predictors of time to clinical stability.
Results:
In this study, children were followed for a total of 2718 person-days, with an incidence rate of 13.50% for clinical stability per 100 person-day observations. The median time to reach clinical stability was 5 days, and approximately 86.97% of pediatric patients with severe pneumonia achieved clinical stability. The most frequently observed abnormal parameter was elevated temperature, while lower oxygen saturation levels were associated with a longer time to clinical stability. Despite a thorough analysis, no statistically significant predictors were identified.
Conclusion:
In this study, most pediatric patients with severe pneumonia remained clinically stable throughout the follow-up period. The median time to clinical stability was 5 days, which was longer compared to other studies. Future research should focus on identifying predictors of delayed clinical stability using alternative analytical methods and larger sample sizes. Efforts should be made by stakeholders to reduce the time to clinical stability for pediatric patients.
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