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Updated: Sep 17, 2025

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
A Case of Refractory Hidradenitis Suppurativa Successfully Treated With Upadacitinib
Itsuki Takei1, Satoko Shibata-Kikuchi2, Ryoma Honda3
1Dermatology, Kyushu University, Fukuoka, JPN.
Abstract:
Hidradenitis suppurativa (HS) is a chronic, disabling inflammatory disease with a high unmet medical need, characterized by persistent, painful skin nodules, abscesses, and draining tunnels. Research on HS is rapidly evolving, with a variety of agents with different mechanisms of action being developed. As several Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways are involved in the pathogenesis of HS, JAK inhibitors represent a promising therapeutic target. Herein, we present a case of severe hidradenitis suppurativa treated with upadacitinib following the failure of adalimumab and secukinumab.
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