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Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
07:48

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

Published on: June 8, 2019

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Long-term outcomes of endovascular therapy for chronic limb-threatening ischemia patients with connective tissue

Shohei Ouchi1, Kao Takehisa2, Naotaka Murata3

  • 1Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-Ku, Tokyo, 113-8421, Japan.

Cardiovascular Intervention and Therapeutics
|July 4, 2025
PubMed

Insights

Endovascular therapy for chronic limb-threatening ischemia in connective tissue disease patients shows poor outcomes, with high amputation and mortality rates. Further therapeutic advancements are crucial for this patient group.

Area of Science:

  • Vascular Surgery
  • Connective Tissue Diseases
  • Ischemia Research

Background:

  • Connective tissue disease (CTD) complicates chronic limb-threatening ischemia (CLTI) management.
  • Revascularization in CTD-CLTI patients often yields poor prognosis and high amputation rates.
  • Limited data exist on long-term endovascular therapy outcomes for CTD-CLTI.

Purpose of the Study:

  • To evaluate the long-term outcomes of endovascular therapy in CLTI patients with CTD.
  • To assess major adverse extremity events, amputation-free survival, and all-cause mortality.
  • To identify the need for improved therapeutic strategies in this population.

Main Methods:

  • Multicenter retrospective cohort study.
  • Inclusion of 44 consecutive CLTI patients with CTD.
  • Analysis of major adverse extremity events, amputation-free survival, and mortality rates.

Main Results:

  • 1-year amputation-free survival: 69.3%; 3-year: 58.3%.
  • 1-year survival rate: 85.5%; 3-year: 70.3%.
  • High rates of major amputations (18.2%) and death (34.1%) observed.

Conclusions:

  • Endovascular therapy for CLTI in CTD patients is associated with significant morbidity and mortality.
  • Current outcomes highlight the urgent need for novel therapeutic approaches.
  • Further research is essential to improve limb salvage and survival rates.

Keywords:
Amputation-free survivalChronic limb-threatening ischemiaConnective tissue diseaseEndovascular therapyMajor adverse extremity events

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