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Changes of Sonic Hedgehog mediated FAK/ERK pathway proteins in amyotrophic lateral sclerosis model mice

Yan Qi1,2, Jin Xu3,2, Ying Wang2

  • 1Department of Neurology, Second Hospital of Shanxi Medical University, Shanxi, China.

Psychopharmacology
|July 4, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Amyotrophic lateral sclerosisERKFAKHSOD1Sonic Hedgehog

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Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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