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Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
Published on: October 30, 2018
Plant- and microalgae-made fish vaccines.
Carlos Angulo1, Martha Reyes-Becerril1, Bernardo Bañuelos-Hernández2
1Immunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD, Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, B.C.S. 23096, Mexico.
Plant and microalgae-based vaccines offer a sustainable solution for fish aquaculture diseases. This review explores their development, application, and potential for industrial adoption in aquatic vaccination.
Area of Science:
- Aquaculture
- Biotechnology
- Immunology
Background:
- Fish aquaculture faces significant disease challenges impacting sustainable food production.
- The development of effective and affordable aquatic vaccines is crucial for the industry.
- Plants and microalgae are established platforms for vaccine production and oral delivery in other sectors.
Purpose of the Study:
- To review the use of plants and microalgae as platforms for producing fish vaccines.
- To outline strategies and tools for efficient vaccine production using these systems.
- To discuss challenges and future prospects for industrial adoption of plant- and microalgae-based fish vaccines.
Main Methods:
- Review of current literature on plant- and microalgae-based vaccine technologies for aquaculture.
- Analysis of workflows, engineering tools, and fish immunology principles relevant to vaccine development.
- Examination of existing plant- and microalgae-made vaccines for fish.
Main Results:
- Plant and microalgae systems show promise for developing cost-effective oral vaccines for fish.
- Specific examples of plant- and microalgae-derived vaccines for aquaculture have demonstrated efficacy.
- Key obstacles to industrial adoption have been identified, with proposed solutions.
Conclusions:
- Plants and microalgae represent viable and sustainable platforms for fish vaccine production.
- Further research and strategic development are needed to overcome current limitations.
- Successful industrial adoption could significantly enhance disease management in global aquaculture.
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