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Updated: Sep 16, 2025
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
Vacuole protein sorting 18 (Vps18) suppresses epithelial growth factor receptor (EGFR) expression and lung
Wuhou Dai1, Shujing Zhang1, Shunfei Yan1
1The Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai, P.R. China.
Abstract:
Lung cancer remains the leading cause of cancer-related deaths worldwide. While lysosomal degradative function is critical for cellular homeostasis, its role in lung cancer pathogenesis remains poorly understood. Here, we identify Vps18 as an important tumor suppressor in murine lung tumorigenesis. Genetic ablation of Vps18 accelerates lung tumorigenesis in LSL-K-Ras mice, accompanied by enhanced tumor cell proliferation. Mechanistically, Vps18 deficiency elevates EGFR protein levels and activates the ERK-MAPK signaling pathway in lung tumors. Strikingly, expression of dominant-negative EGFR (dnEGFR) partially suppresses the tumor-promoting effects of Vps18 loss. Our findings unveil a novel Vps18-EGFR-ERK axis in lung cancer and may inform the development of targeted therapeutic strategies.
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