Genotype pattern of factor V and XIII abnormalities in the Iranian population: A meta-analysis

Hemostatic disorders are significantly associated with morbidity and mortality. Hence, the examination of coagulation abnormalities is a cornerstone of prevention and therapy. This meta-analysis aimed to determine the genotype pattern of Factor V (FV) and XIII (FXIII) abnormalities in the Iranian population. Methods The search strategy was conducted in electronic databases including Web of Science, PubMed, Scopus, SID, ProQuest, and Magiran, covering the period from May 10,1990, to May 10, 2019, following the PRISMA principles. Studies of various designs,including cross-sectional, cohort, experimental, and case-control studies, were included based on specific criteria, without any limitations on gender or language.Results Out of 10,449 research entries, 10,432 were screened, with 132 abstracts and titles analyzed, 23 full articles reviewed, and ultimately 11 studies included in the metaanalysis. The mutation c.1691 G>A: GG (95 % CI: 0.98) had the greatest occurrence rate in FV deficient patients, while the 34Val/Leu mutation (95 % CI: 1.00) was detected as the most prevalent mutation in instances of FXIII insufficiency. Conclusions Specific FV and XIII gene mutations are associated with increased risk for thrombotic conditions. FV deficiency with the c.1691 G>A mutation was prevalent in stroke patients, while FXIII deficiency with the 34Val/Leu mutation was linked to recurrent miscarriages.