RONS clearing TePt @ sodium carboxymethyl cellulose nanozymes for chronic enteritis therapy

Chronic enteritis is a prevalent inflammatory disease that can progress to acute enteritis and even intestinal cancer if not promptly treated. This inflammation is often associated with the overproduction of reactive oxygen and nitrogen species (RONS), which disrupt the cellular redox homeostasis and induce significant damage to cells and tissues. Therefore, the targeted removal of RONS at inflamed sites has emerged as a promising therapeutic strategy for chronic enteritis. In this study, the TePt nanorods (TP) with good physiological stability, biosafety and antioxidant activities were developed to alleviate chronic enteritis. TP demonstrated pH-dependent enzymatic activities, effectively scavenging reactive oxygen species through their superoxide dismutase and catalase activities, as well as clearing reactive nitrogen species under neutral conditions. At the cellular level, TP could eliminate intracellular RONS and protect cells from oxidative stress-induced damage. In a dextran sulfate sodium (DSS)-induced mouse model of chronic enteritis, the intragastric administration of TP combined with sodium carboxymethyl cellulose (CMC) significantly inhibited the expression of proinflammatory cytokine, restored redox homeostasis, and promoted bowel repair without noticeable adverse effects. This study provides new insights into the design of antioxidant nanozymes for the treatment of chronic enteritis.