Related Experiment Video

Updated: Sep 16, 2025

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

8.9K

Perinatal Airway Risk for Individuals With Isolated Cleft Spectrum

Johanna L Ellefson1, Samantha J Barr1, Maya N Matabele1

  • 1University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|July 7, 2025
PubMed

Insights

Infants with isolated cleft lip, isolated cleft palate, or cleft lip and palate require more airway interventions at birth, experiencing worse outcomes. This highlights the need for specialized delivery planning for these neonates.

Area of Science:

  • Neonatal care
  • Pediatric surgery
  • Craniofacial anomalies

Background:

  • Cleft lip and palate anomalies can be associated with neonatal airway obstruction.
  • Limited data exists on the management and outcomes of airway interventions in isolated cleft spectrum disorders.

Purpose of the Study:

  • To investigate the incidence, interventions, and outcomes of airway procedures in neonates with isolated cleft lip (iCL), isolated cleft palate (iCP), and cleft lip and palate (CLP).

Main Methods:

  • Utilized deidentified birth hospitalization data from the Healthcare Cost and Utilization Project Kids' Inpatient Database (2000-2019).
  • Identified and categorized patients with iCL, iCP, and CLP using ICD codes.
  • Analyzed demographics, airway interventions on day of life 0 or 1, complications, and survival, comparing cleft spectrum to unaffected groups using Rao-Scott chi-square tests.

Main Results:

  • The incidence of isolated cleft spectrum was 1.3 per 1000 birth visits.
  • Airway intervention on day of life 0 or 1 occurred in 5.0% of the cleft group versus 1.7% in the unaffected group (P ≤ .01).
  • Neonates with cleft spectrum undergoing airway intervention had higher rates of hypoxic complications or mortality.

Conclusions:

  • Individuals with isolated cleft spectrum experience significantly higher rates of perinatal airway interventions compared to unaffected neonates.
  • These interventions are associated with poorer outcomes, including increased hypoxic complications and mortality.
  • Findings underscore the importance of delivery planning, emphasizing the need for appropriate neonatal services for affected infants.

Keywords:
airway obstructioncleft lipcleft lip and palatecleft palateinterventionpediatricsupper airway obstruction

More Related Videos

Transuterine Fetal Tracheal Occlusion Model in Mice06:31

Transuterine Fetal Tracheal Occlusion Model in Mice

Published on: February 5, 2021

3.2K
Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles07:37

Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles

Published on: July 20, 2015

11.1K

Related Concept Videos

Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
109
Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
1.2K
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
91
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
448
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
60.4K
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
227