Related Experiment Video
Updated: Sep 16, 2025
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Association Between Low Circulating Omentin-1, Vitamin D, Antioxidants, and Trace Elements Imbalances in Women with
Chiman H Sulaiman1, Lina Y Mohammed2, Mohammed A Hami1
1Chemistry Department, College of Science, University of Zakho, Zakho, Iraq.
Background And Objective:
Omentin-1, a novel adipokine with anti-inflammatory properties, may have a role in the pathophysiology of Subclinical hypothyroidism (SCHT). However, its association with antioxidants, vitamin D, and trace elements imbalances in SCHT remain underexplored. This study aimed to evaluate the association between low circulating Omentin-1 with vitamin D, antioxidants, and trace elements imbalances in women with newly diagnosed subclinical hypothyroidism.
Method:
Fifty newly diagnosed subclinical hypothyroid females aged 18-50 years and 40 healthy females matched in age with cases are enrolled in the current study. Thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and Vitamin D were measured using electrochemiluminescence assay. Serum iron (Fe) is analyzed by a photometric measuring unit. Serum zinc (Zn), magnesium (Mg), and copper (Cu) were quantified using a colorimetric assay. Serum glutathione-s-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) were examined by spectrophotometer. Omentin-1 is analyzed by the Enzyme-Linked Immunosorbent Assay (ELISA).
Result:
Omentin-1 levels are markedly reduced in women with SCHT compared with healthy controls. Moreover, there is a substantial decrease in Serum Zn, Mg, SOD, GST, and vitamin D and a significant increase in Cu/Zn and Cu/Mg ratios among SCHT group. Omentin-1 had a substantial positive correlation with CAT, SOD, and Vitamin D, however a significant negative link was observed between omentin-1 and TSH.
Conclusion:
The present study concluded that women with newly diagnosed subclinical hypothyroidism demonstrate significant changes in omentin-1, antioxidant enzymes, trace elements, and their ratios. Furthermore, low circulating omenin-1 in women with newly diagnosed SCHT is correlated with deficiencies in vitamin D, antioxidant enzymes, and trace elements imbalances.
Related Concept Videos
02:07Oogenesis
01:20Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
01:18Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:22Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
01:30Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...