A randomized safety study of tolerance to table rotation in dynamic trajectory radiotherapy in healthy volunteers

This study aimed to show that table movement of dynamic trajectory radiotherapy (DTRT) does not induce more motion sickness than standard-of-care non-coplanar volumetric modulated arc therapy (ncVMAT). Forty-one healthy volunteers underwent dry-runs of DTRT and ncVMAT in four different, randomly allocated sequences. The primary outcome was the Motion Sickness Assessment Questionnaire (MSAQ) summary score. The average change in MSAQ summary score before to after dry-runs was 1.88 for DTRT and 1.62 for ncVMAT. The difference between both techniques was 0.26 [95% CI: -0.24 to 0.75]; the CI demonstrated non-inferiority of DTRT to ncVMAT for motion sickness in healthy volunteers.