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Updated: Sep 16, 2025

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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Rapamycin for longevity: the pros, the cons, and future perspectives.

Kelley M Roark1, Philip H Iffland1

  • 1Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.

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|July 7, 2025
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Rapamycin inhibits the mTOR pathway, a key regulator of aging and cell growth. This drug shows promise for anti-aging therapies and treating age-related diseases by targeting this pathway.

Keywords:
agingepilepsyeverolimusmTORsirolimus

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Area of Science:

  • Biomedical Research
  • Pharmacology
  • Gerontology

Background:

  • Rapamycin, an antifungal antibiotic, is crucial in biomedical research.
  • It exhibits immunosuppressive properties and is explored for anti-aging and seizure treatments.
  • The mechanistic target of the rapamycin (mTOR) pathway regulates cell growth and survival, and its activity is linked to aging and disease.

Purpose of the Study:

  • To summarize the mTOR pathway and rapamycin's impact on it.
  • To review rapamycin's current use in aging and longevity research.
  • To discuss knowledge gaps, challenges, and potential of rapamycin for age-related disease prevention.

Main Methods:

  • Literature review of rapamycin's mechanism of action.
  • Analysis of rapamycin's role in mTOR pathway inhibition.
  • Examination of current research on rapamycin for aging and longevity.

Main Results:

  • Growing evidence links mTOR pathway activity to accelerated aging and age-related diseases.
  • Rapamycin and its analogs are used off-label for age-related condition prevention.
  • Current FDA-approved uses include transplant rejection and seizures in Tuberous Sclerosis Complex.

Conclusions:

  • Rapamycin's mTOR inhibition offers potential for preventing aging and related diseases.
  • Further research is needed to address knowledge gaps and potential pitfalls.
  • Lessons from evrolimus's FDA approval for TSC seizures inform future therapeutic development.