Related Experiment Video
Updated: May 10, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
Published on: August 21, 2016
[Pierre Tiollais (1934-2024), a pioneer in genetic engineering with a lifelong commitment to the hepatitis B virus]
Christian Bréchot1, Patrick Charnay2, Hugues de Thé3
1University of South Florida, Tampa, États-Unis, Global virus network.
Abstract:
Pierre Tiollais, a French physician-biologist, died on August 5, 2024, at 89. He is celebrated for cloning and sequencing the hepatitis B virus (HBV) genome and developing one of the first recombinant HBV vaccines. Professor at the Pasteur Institute and the University Paris VII (now University Paris Cité), Pierre Tiollais has played a key role in the application of molecular biology and genetic engineering in medical research, notably in the fight against HBV and human immunodeficiency virus (HIV). His work has helped saving millions of lives through vaccination campaigns. Pierre Tiollais was also renowned for his benevolent mentorship and commitment to the scientific community.
Related Concept Videos
The DNA Helix
Animal Mitochondrial Genetics
The DNA Helix
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Pharmacogenomics: Identification of New Drug Targets
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...

