Related Experiment Video

Updated: Sep 16, 2025

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

9.9K

Fetal Therapy for Renal Anomalies and Anhydramnios

Percy Pacora-Portella1, Edgar Hernandez-Andrade, Anthony Johnson

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Fetal Intervention, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas.

Clinical Obstetrics and Gynecology
|July 7, 2025
PubMed

Insights

Congenital anomalies of the kidneys and urinary tract (CAKUT) impact many newborns, leading to kidney disease. Further research is crucial for better management of these serious developmental defects.

Area of Science:

  • Pediatric Nephrology
  • Developmental Biology
  • Medical Ultrasound

Background:

  • Congenital anomalies of the kidneys and urinary tract (CAKUT) affect 1 in 465 live births.
  • CAKUT anomalies represent 28-33% of neonatal ultrasound findings.
  • CAKUT is a primary cause of chronic and end-stage kidney disease in children.

Purpose of the Study:

  • To highlight the significance of CAKUT in pediatric kidney disease.
  • To underscore the link between CAKUT, amniotic fluid, and potential complications.
  • To emphasize the need for improved management strategies and further research.

Main Methods:

  • Review of existing literature on CAKUT prevalence and impact.
  • Analysis of the role of amniotic fluid volume in CAKUT.
  • Evaluation of current treatment options and their limitations.

Main Results:

  • CAKUT accounts for 40-50% of pediatric end-stage kidney disease.
  • Decreased amniotic fluid due to CAKUT can cause severe complications.
  • Existing treatments like amnioinfusion and shunting have risks and uncertain outcomes.

Conclusions:

  • CAKUT is a critical condition in pediatric nephrology with significant long-term consequences.
  • Effective management requires addressing amniotic fluid disturbances and treatment risks.
  • Further research is essential to develop safer and more effective interventions for CAKUT.

Keywords:
amnioinfusionrenal anomaliesvesicoamniotic shunt

More Related Videos

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model06:43

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

9.7K
Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

19.8K

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.8K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
48
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
78
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
1.4K