Liberal Versus Restrictive Oxygenation Targets in Acute Heart Failure-A Protocol for a Systematic Review With
Ida Arentz Taraldsen1, Jasmin Dam Lukoschewitz1, Sandra Tonning1
1Department of Cardiology, Copenhagen University Hospital-Amager Hvidovre Hospital, Copenhagen, Denmark.
Acta Anaesthesiologica Scandinavica
|July 7, 2025
Summary
This systematic review will compare liberal versus restrictive oxygen therapy targets in acute heart failure (AHF). We hypothesize that restrictive oxygen strategies reduce mortality and adverse events in AHF patients.
Area of Science:
- Cardiology
- Pulmonology
- Critical Care Medicine
Background:
- Supplemental oxygen therapy is a standard treatment for acute heart failure (AHF).
- Optimal oxygen saturation targets and strategies in AHF remain unclear.
- Clinical uncertainty necessitates a comparison of liberal versus restrictive oxygenation.
Purpose of the Study:
- To conduct a systematic review comparing liberal and restrictive oxygenation targets in AHF.
- To hypothesize that restrictive oxygen strategies reduce mortality and adverse events.
Main Methods:
- Systematic review and meta-analysis protocol based on Cochrane Collaboration and PRISMA guidelines.
- Inclusion of all randomized clinical trials comparing restrictive versus liberal oxygenation in AHF.
- Comprehensive database searches (MEDLINE, Embase, Web of Science, CENTRAL) and clinical trial registries.
- Risk of bias assessment using Cochrane Risk of Bias tool.
- Meta-analysis and trial sequential analysis, with evidence certainty evaluated using Grading of Recommendations Assessment.
Main Results:
- N/A - Protocol for a future systematic review.
Conclusions:
- This protocol outlines a systematic review and meta-analysis to provide evidence on oxygenation targets in AHF.
- The findings aim to guide clinicians in optimizing oxygen treatment strategies for AHF patients.
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