Duration of COVID-19 symptoms in children: a longitudinal study in a Rio de Janeiro favela, Brazil

Fernanda Esthefane Garrides Oliveira1, Leonardo Bastos2, Raquel de Vasconcellos Carvalhães de Oliveira3

  • 1Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil fergarrides@gmail.com.

BMJ Open
|July 7, 2025
PubMed

Insights

Children infected with SARS-CoV-2 in Brazil experienced longer COVID-19 recovery times than reported elsewhere. Persistent symptoms were observed in 9.5% of pediatric cases, highlighting socioeconomic context impacts.

Area of Science:

  • Pediatric infectious diseases
  • Epidemiology
  • Public health

Background:

  • COVID-19 duration in children varies, with some facing prolonged recovery.
  • Understanding pediatric SARS-CoV-2 recovery is crucial, especially in vulnerable communities.

Purpose of the Study:

  • To investigate the time to symptom resolution after SARS-CoV-2 infection in Brazilian children.
  • To identify factors influencing recovery duration in a community setting.

Main Methods:

  • Prospective community-based cohort study in Rio de Janeiro, Brazil.
  • Follow-up via home visits and telephone monitoring of 253 SARS-CoV-2 positive children (aged 2-14).
  • Recovery time analyzed using Kaplan-Meier curves.

Main Results:

  • Median recovery time was 11 days (IQR: 7-16 days).
  • Two inflection points at 16 and 34 days indicated prolonged symptom duration.
  • Children infected during the Omicron wave and boys showed varied recovery patterns; 9.5% had symptoms >33 days.

Conclusions:

  • Pediatric COVID-19 recovery in this vulnerable Brazilian setting was longer than in other countries.
  • Socioeconomic factors likely influence recovery dynamics.
  • Findings are vital for understanding pediatric COVID-19 in community contexts.
Abstract

Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.5K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
31.5K
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
252
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
697
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.6K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K