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Duration of COVID-19 symptoms in children: a longitudinal study in a Rio de Janeiro favela, Brazil
Fernanda Esthefane Garrides Oliveira1, Leonardo Bastos2, Raquel de Vasconcellos Carvalhães de Oliveira3
1Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil fergarrides@gmail.com.
Insights
Children infected with SARS-CoV-2 in Brazil experienced longer COVID-19 recovery times than reported elsewhere. Persistent symptoms were observed in 9.5% of pediatric cases, highlighting socioeconomic context impacts.
Area of Science:
- Pediatric infectious diseases
- Epidemiology
- Public health
Background:
- COVID-19 duration in children varies, with some facing prolonged recovery.
- Understanding pediatric SARS-CoV-2 recovery is crucial, especially in vulnerable communities.
Purpose of the Study:
- To investigate the time to symptom resolution after SARS-CoV-2 infection in Brazilian children.
- To identify factors influencing recovery duration in a community setting.
Main Methods:
- Prospective community-based cohort study in Rio de Janeiro, Brazil.
- Follow-up via home visits and telephone monitoring of 253 SARS-CoV-2 positive children (aged 2-14).
- Recovery time analyzed using Kaplan-Meier curves.
Main Results:
- Median recovery time was 11 days (IQR: 7-16 days).
- Two inflection points at 16 and 34 days indicated prolonged symptom duration.
- Children infected during the Omicron wave and boys showed varied recovery patterns; 9.5% had symptoms >33 days.
Conclusions:
- Pediatric COVID-19 recovery in this vulnerable Brazilian setting was longer than in other countries.
- Socioeconomic factors likely influence recovery dynamics.
- Findings are vital for understanding pediatric COVID-19 in community contexts.
Objectives:
COVID-19 in children is generally of short duration, but some may take longer to recover. This study investigated the time to symptom resolution following SARS-CoV-2 infection among children in a community setting on the outskirts of an urban centre in Brazil.
Design:
Prospective cohort study.
Setting:
This is a community-based cohort of children living in Manguinhos, a favela in Rio de Janeiro. The cohort was followed through home visits and telephone monitoring of symptoms. The analysis focused on symptomatic children from this cohort with confirmed SARS-CoV-2 infection. Recovery time was defined as the interval between the first date with symptoms and the first date without symptoms following a positive SARS-CoV-2 test.
Participants:
A total of 1276 children (boys and girls aged 2-<14 years) were recruited between 2020 and 2022, with 253 testing positive for SARS-CoV-2. The inclusion criterion was SARS-CoV-2-positive children, while the exclusion criteria were loss to follow-up and asymptomatic cases during the acute phase of COVID-19.
Outcome Measure:
COVID-19 recovery time, assessed based on change points on the symptom persistence probability curve (Kaplan-Meier).
Results:
Among children who tested positive, 148 (60%) were symptomatic. The median recovery time was 11 days (IQR: 7-16). Two inflection points were identified on the Kaplan-Meier curve: days 16 and 34. Children who were ill during the Omicron wave took longer to recover. More boys became asymptomatic within the first 15 days; about 93% of girls recovered by day 33, and boys were more common among those who recovered in ≥34 days. Children aged 6-<14 years often recovered within 2 weeks; however, both this group and the 2-<6 years group constituted the majority of those with delayed recovery.
Conclusions:
Among children from a vulnerable area in Rio de Janeiro, recovery time was longer than that reported in other countries, with 9.5% of children experiencing persistent symptoms for more than 33 days. These findings are crucial for understanding the implications of COVID-19 in specific socioeconomic contexts and the dynamics of paediatric recovery in community settings.
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