Related Experiment Video
Updated: Sep 16, 2025
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Small Intestinal Bacterial Overgrowth in Patients With Severe Alcoholic Hepatitis: Frequency and Predictors
Venkatesh Vaithiyam1, Sanjeev Sachdeva1, Payila Aneesh1
1Gastroenterology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, IND.
Background And Aims:
Small intestinal bacterial overgrowth (SIBO) is a gut microbiota-related disorder characterized by excessive bacterial density and/or abnormal microbiota composition in the small intestine. We aimed to evaluate the frequency of SIBO in patients with severe alcoholic hepatitis (SAH) and to identify independent predictors.
Methods:
We included 60 consecutive patients with SAH and 30 healthy controls (HC). After an overnight fast, SIBO was evaluated using the glucose hydrogen breath test (GHBT) with 100 g of glucose. A sustained increase in breath hydrogen or methane levels > 12 parts per million (ppm) above the basal level was considered diagnostic for SIBO.
Results:
SIBO was more frequent in patients with SAH than HC (15/60 (25.0%) vs. 1/30 (3.3%), p = 0.017). In the univariate analysis, globulin levels, total protein levels, and predominant methane producer status significantly differed between patients with and without SIBO. In the multivariate analysis, the predominant methane producer status increased the risk of SIBO by 17.44 times (adjusted odds ratio: 17.44 (95% CI (1.9-154.04)), p = 0.001).
Conclusions:
This study showed that SIBO is a more common finding in patients with SAH than in HC. The predominant methane producer status independently predicted the SIBO in these patients.
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...