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Recent progress in stimuli-responsive DNA-based logic gates: Design, working principles and biological applications
Ling Sum Liu1,2, Hoi Man Leung1, Yuzhen Cai1
1Department of Chemistry and State Key Laboratory of Marine Pollution City University of Hong Kong Kowloon Tong Hong Kong SAR China.
Smart Molecules : Open Access
|July 8, 2025
Summary
Stimuli-responsive DNA logic gates offer programmable computation for nanotechnology. These DNA-based gates are triggered by various inputs for applications in biosensing and molecular computing.
Area of Science:
- Synthetic biology
- Nanotechnology
- Molecular computing
Background:
- DNA-based logic gates leverage DNA's properties for programmable computation.
- These gates respond to specific stimuli, integrating biological and nanoscale systems.
Purpose of the Study:
- To provide a comprehensive review of stimuli-responsive DNA-based logic gates.
- To highlight advancements in design, working principles, and applications.
Main Methods:
- Review of literature on DNA logic gates.
- Categorization of gates based on stimuli (metal ions, pH, oligonucleotides, small molecules, proteins, light).
- Analysis of applications in imaging, biosensing, drug delivery, synthetic biology, and molecular computing.
Main Results:
- Progress in designing diverse DNA logic gates responsive to various stimuli.
- Demonstrated applications in advanced biosensing, targeted drug delivery, and molecular computation.
- Significant advancements in integrating these gates into complex biological systems.
Conclusions:
- Stimuli-responsive DNA logic gates represent a significant advancement in nanotechnology.
- Future prospects include enhanced molecular computing and sophisticated biosensing platforms.
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