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Malignant Hidroacanthoma Simplex: A Case Report.

Xiangxiang Ren¹, Tianhao Xie¹, Lingyun Liu¹

¹Department of General Surgery, Affiliated Hospital of Hebei University, Baoding, China.

Case Reports in Dermatology

|July 8, 2025

Summary

Malignant hidroacanthoma simplex (MHS), a rare skin neoplasm, presents a diagnostic challenge. Complete surgical excision is effective for MHS confined to the epidermis, with no recurrence observed in this case.

Keywords:

Malignant hidroacanthoma simplex Surgical resection

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Malignant hidroacanthoma simplex (MHS) is an extremely rare cutaneous neoplasm.
Limited documented cases present diagnostic and management challenges.

Purpose of the Study:

To report a distinctive case of MHS with a prolonged clinical course.
To emphasize diagnostic challenges and management outcomes for MHS.

Main Methods:

A case presentation of a 64-year-old female with a 2-decade history of a right lumbar mass.
Clinical examination revealed a solitary, proliferative plaque.
Histopathological analysis showed epidermal tumor cells without dermal invasion.

Main Results:

The patient presented with a 3.5 cm x 4.0 cm reddish-brown plaque.
Histopathology confirmed MHS confined to the epidermis.
Complete surgical excision resulted in no recurrence or metastasis at 15 months follow-up.

Conclusions:

MHS exhibits an indolent but locally persistent nature.
Complete surgical excision is the primary management for non-invasive MHS.
Long-term follow-up is essential for monitoring potential recurrence.