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The Relationship Between Prediabetes and Peripheral Neuropathy-A Systematic Review and Meta-Analysis.
Roya Riahi1, Setayesh Seindareh2,3, Ashraf Aminorroaya4
1Epidemiology and Biostatistics Department, School of Public Health, Isfahan University of Medical Science, Isfahan, Iran.
European Journal of Neurology
|July 8, 2025
Summary
Pre-diabetes is linked to peripheral neuropathy, affecting nerve function and sensation. Early lifestyle interventions are crucial for managing this risk and preventing complications.
Area of Science:
- Endocrinology
- Neurology
- Public Health
Background:
- Pre-diabetes represents a significant public health concern, characterized by elevated blood glucose levels below the diagnostic threshold for type 2 diabetes.
- Neuropathy, a disorder affecting peripheral nerves, can lead to significant morbidity and reduced quality of life.
Purpose of the Study:
- To systematically review and meta-analyze existing research on the association between pre-diabetes and the development of neuropathy.
- To quantify the risk of neuropathy in individuals with pre-diabetes.
Main Methods:
- A systematic review and meta-analysis of original human studies were conducted.
- Methodological quality was assessed using NHLBI tools; heterogeneity was evaluated using I² statistics, Galbraith plots, Egger's, and Begg's tests.
- Random-effects restricted model was employed for meta-analysis.
Main Results:
- A statistically significant association was found between pre-diabetes and peripheral neuropathy.
- Pre-diabetes was linked to increased neuropathy assessment metrics (e.g., impaired vibration perception, neuropathic pain) (SMD 0.23 [0.14; 0.33]).
- Conversely, pre-diabetes was associated with decreased metrics (e.g., corneal nerve fiber density) (SMD -1.04 [-1.05; -0.57]).
Conclusions:
- Pre-diabetes is a significant risk factor for peripheral neuropathy.
- Preventive strategies and lifestyle interventions are essential for individuals with pre-diabetes to mitigate neuropathy risk.
- Policymakers should prioritize interventions to address this growing health issue.
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