Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

81
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
81
Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

49
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
49
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

349
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
349
Cardiopulmonary Resuscitation I: Adult01:21

Cardiopulmonary Resuscitation I: Adult

93
Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
93

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of Prokinetic Agents in Adult ICU Patients: An International Inception Cohort Study (PATIENCE).

Acta anaesthesiologica Scandinavica·2026
Same author

Vitamin C appears harmful in patients after out-of-hospital cardiac arrest treated in the intensive care unit.

Intensive care medicine·2026
Same author

Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE): A Protocol for a Pre-Planned Sub-Study of a Randomized Clinical Trial.

Acta anaesthesiologica Scandinavica·2026
Same author

Developing a Core Outcome Measurement Set for Adult ICU Patients, the CoreMS-ICU-A Protocol.

Acta anaesthesiologica Scandinavica·2026
Same author

Ventilation strategies and outcomes after out-of-hospital cardiac arrest: protocol for a pre-planned sub-analysis of the STEPCARE trial.

BMJ open·2026
Same author

Preferences for Blood Glucose Management in Adult Intensive Care Unit Patients-An International Survey.

Acta anaesthesiologica Scandinavica·2026

Related Experiment Video

Updated: Sep 16, 2025

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
07:18

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

Published on: April 14, 2023

1.9K

Innate Immune Response After Cardiac Arrest (INNATUS): A Study Protocol for an Observational Single-Center Pilot

Asser M J Seppä1, Huai Hui Wong2,3, Luz E Cabrera2,3

  • 1Division of Intensive Care Medicine, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Acta Anaesthesiologica Scandinavica
|July 8, 2025
PubMed
Summary

This study investigates inflammatory marker patterns in cardiac arrest (CA) patients, revealing associations between these markers, organ failure severity, and long-term neurological outcomes after resuscitation.

Keywords:
cardiac arrestinflammationinnate immunityresuscitationsystems immunology

More Related Videos

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
07:49

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

1.8K
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

896

Related Experiment Videos

Last Updated: Sep 16, 2025

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
07:18

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

Published on: April 14, 2023

1.9K
Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
07:49

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

1.8K
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

896

Area of Science:

  • Immunology
  • Critical Care Medicine
  • Systems Biology

Background:

  • Post-cardiac arrest syndrome (PCAS) involves a complex systemic inflammatory response.
  • Elevated inflammatory markers correlate with increased mortality and poor neurological outcomes in cardiac arrest (CA) survivors.
  • The interplay of inflammatory mediators in PCAS pathogenesis remains incompletely understood.

Purpose of the Study:

  • To examine patterns of inflammatory markers in adult CA patients.
  • To investigate the association between these inflammatory patterns and organ failure severity.
  • To determine the relationship between inflammatory profiles and 6-month neurological outcomes.

Main Methods:

  • Prospective observational single-center study of 40 CA patients and 40 coronary artery bypass graft (CABG) controls.
  • Systemic immunology analysis using proteomic, transcriptomic, and flow cytometry on serial blood samples.
  • Assessment of organ failure (SOFA score) and neurological outcome (Modified Rankin Scale) at 6 months post-ROSC.

Main Results:

  • Identification of distinct immunological response profiles in PCAS patients.
  • Correlation analysis linking specific inflammatory patterns to the severity of organ dysfunction.
  • Association of immunological profiles with neurological recovery at 6 months post-cardiac arrest.

Conclusions:

  • Inflammatory marker patterns provide insights into PCAS pathogenesis and patient stratification.
  • Understanding these patterns can guide the development of targeted anti-inflammatory therapies.
  • This systems immunology approach aids in predicting organ failure and neurological outcomes in CA survivors.