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Updated: Sep 16, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
N-Phosphinoylaminophthalimide: a phosphinoyl radical precursor applied in phosphinoyl-substituted phenanthridine and
Zhiqiang Yang1, Ziwei Li1, Yunfangting Wei1
1School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Xiasha West Higher Education District, Hangzhou, 310018, China. xuzefeng@zstu.edu.cn.
Abstract:
A new phosphinoyl radical precursor, N-phosphinoylaminophthalimide (NPAPI), was developed. The precursor exhibits several practical advantages: facile synthesis from commercially available starting materials, cost-effectiveness at scale, and excellent air and moisture stability under ambient storage conditions. Phosphinoyl radical was generated under basic and oxidative conditions, and captured by isonitrile and olefin, yielding phosphinoyl-substituted phenanthridines and α-phosphinoyl ketones, respectively. This methodology enables phosphinoyl radical-mediated operationally simple synthesis of organophosphorus compounds.
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