Related Experiment Video
Updated: Jul 5, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
Eosinophilic esophagitis with refractory response in a pediatric patient: A case report
Isamar De Agrela-Mendes1, Margarita Tomás-Perez2
1Servicio de Alergología, Hospital Universitario La Paz, Madrid, Spain. Isamardeagrela@gmail.com.
Background:
The treatment of eosinophilic esophagitis (EoE) is based on diets or drugs, with either being the first choice. Proton pump inhibitor (PPI) or swallowed topical corticosteroids (STC) are classically used, and more recently the use of dupilumab has been described as a therapeutic option.
Case Report:
A pediatric patient with difficult-to-manage eosinophilic esophagitis, diagnosed before the age of 2 years, in which the simultaneous use of triple pharmacological therapy (Dupilumab, PPI and STC) has been necessary for the histological control of the disease.
Conclusion:
It is a case of interest since in current guidelines the use of combined pharmacological therapies is not recommended or fully described. In addition, it is a case in which a good response to treatment with dupilumab is observed despite not meeting the indication criteria of the pharmacological label, in terms of age and weight.
Related Concept Videos
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Gastroesophageal Reflux Disease

