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[Wheat-dependent exercise-induced anaphylaxis: The diagnostic utility of Omega-5 Gliadin in two clinical cases from
Liz Veramendi-Espinoza1, César Galván1, Rafael Durán2
1Emedic Salud, Lima, Perú.
Background:
Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare, potentially life-threatening condition triggered by wheat ingestion followed by physical activity.
Case Report:
This report describes two cases of young individuals in Lima, Peru, diagnosed with WDEIA. The diagnosis was confirmed through skin prick testing and the Allergy Explorer2 (ALEX-2) microarray, identifying omega-5gliadin (Tria19) as the main allergen. Both patients experienced episodes of anaphylaxis, one of which required adrenaline administration.
Conclusion:
The importance of molecular diagnostics to confirm WDEIA is highlighted, and preventive strategies such as avoiding wheat before exercise and emergency plans are discussed. These cases underscore the need for greater clinical awareness and improved access to life-saving interventions in resource-limited regions.
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