Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Feasibility of the Meta Quest 3 for upper limb kinematic analysis: accuracy, consistency, agreement and reliability.

Journal of neuroengineering and rehabilitation·2026

Same author

Effect of a virtual walking and therapeutic exercise-based intervention on gait and balance in people with incomplete spinal cord injury.

PM & R : the journal of injury, function, and rehabilitation·2026

Same author

Validity and Reliability of a Laser Pointer Device to Assess Knee Proprioception in Healthy and Active Individuals.

Physiotherapy research international : the journal for researchers and clinicians in physical therapy·2026

Same author

Effects of transcranial direct current stimulation on pain and function in patients with knee osteoarthritis: A systematic review and meta-analysis.

PM & R : the journal of injury, function, and rehabilitation·2026

Same author

Robotic assessment of proprioception in individuals with patellar tendinopathy: A feasibility and pilot study.

Clinical biomechanics (Bristol, Avon)·2026

Same author

Application of functional regression in biomechanical assessment of neck disability: Selection of clinically relevant variables.

PloS one·2026

Same journal

Reduced mechanical strength correlates with decreased elastin content in aortic intima-media tissue: association with dissection in human ascending aortas.

Medical & biological engineering & computing·2026

Same journal

How plaque morphology and stenosis severity govern stent-artery interaction and deployment outcomes: a computational study.

Medical & biological engineering & computing·2026

Same journal

Investigating a relation between amyloid beta plaque burden and accumulated neurotoxicity caused by amyloid beta oligomers.

Medical & biological engineering & computing·2026

Same journal

A robot-assisted eye positioning method with high precision and repeatability for ocular particle therapy: mechanical and geometric assessment.

Medical & biological engineering & computing·2026

Same journal

Enhanced puncture event detection for teleoperated needle insertion robotic system.

Medical & biological engineering & computing·2026

Same journal

Energy-efficient real-time 4-stage sleep classification at 10-second resolution.

Medical & biological engineering & computing·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 16, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

Non-specific neck pain evaluation using functional linear models with the limma correction.

Elisa Aragón-Basanta¹, Guillermo Ayala², Álvaro Page³

¹Instituto Universitario de Ingeniería Mecánica y Biomecánica, Universitat Politècnica de València, Camino de Vera s/n, Valencia, 46022, Spain. mearba@doctor.upv.es.

Medical & Biological Engineering & Computing

|July 8, 2025

Summary

This summary is machine-generated.

Neck disability and age significantly impact neck movement velocity and acceleration in non-specific neck pain patients. Angular curves were not significantly affected, highlighting the importance of analyzing velocity and acceleration data together.

Keywords:

Benjamini-Hochberg correction Functional data analysis Limma Multiple linear regression Neck disability index

More Related Videos

Chuzhen Therapy as a Non-Invasive Traditional Chinese Therapy for Neck Pain

Chuzhen Therapy as a Non-Invasive Traditional Chinese Therapy for Neck Pain

Published on: June 6, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Related Experiment Videos

Last Updated: Sep 16, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

Chuzhen Therapy as a Non-Invasive Traditional Chinese Therapy for Neck Pain

Chuzhen Therapy as a Non-Invasive Traditional Chinese Therapy for Neck Pain

Published on: June 6, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Area of Science:

Biomechanics
Clinical Biomechanics
Musculoskeletal Research

Background:

Non-specific neck pain is prevalent, affecting daily function.
Understanding neck kinematics is crucial for assessing disability.
Existing kinematic analyses may not fully capture the nuances of neck pain.

Purpose of the Study:

To analyze the relationship between neck disability and neck flexion-extension kinematics.
To evaluate the influence of the Neck Disability Index (NDI), age, sex, and neck length on kinematic parameters.
To compare classical regression with empirical Bayes approaches for kinematic analysis.

Main Methods:

Functional analysis of angle, velocity, and acceleration curves during neck movement.
Regression models, including classical and limma (Linear Models for Microarray Data) approaches.
Adjustment of p-values using the Benjamini-Hochberg method to control the False Discovery Rate (FDR).

Main Results:

Significant differences observed between raw and adjusted p-values, indicating spurious findings in unadjusted analyses.
Neck length did not significantly affect velocity or acceleration curves after FDR adjustment.
Neck Disability Index (NDI) and age significantly influenced velocity and acceleration curves, but not angular curves.

Conclusions:

Adjusted p-values revealed that NDI and age are key predictors of neck movement velocity and acceleration.
Angular kinematic curves alone are insufficient; velocity and acceleration data provide complementary insights.
Velocity and acceleration curves should be analyzed concurrently in neck kinematics studies for non-specific neck pain.