Related Experiment Video
Updated: Sep 16, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
GPs' perspectives on GLP-1RAs for obesity management: a qualitative study in England
Sabrina Keating1, Cervantée Wild2, Jadine Scragg3
1University of Oxford, Nuffield Department of Primary Care Health Sciences, Radcliffe Primary Care Building, Oxford, UK.
General practitioners (GPs) in England support using glucagon-like peptide-1 receptor agonists (GLP-1RAs) for obesity management. However, they worry about resource limitations and ensuring these drugs are part of a holistic approach.
Area of Science:
- General Practice
- Pharmacology
- Public Health
Background:
- Rising obesity rates necessitate effective primary care treatments.
- General practitioners (GPs) in the NHS report low confidence in current obesity management options.
- Glucagon-like peptide-1 receptor agonists (GLP-1RAs) show promise for weight management but lack primary care pathways.
Purpose of the Study:
- To explore NHS GPs' perspectives on GLP-1RAs for weight management.
- To understand potential challenges and facilitators for integrating GLP-1RAs into primary care.
- To assess GP views on the role of GLP-1RAs within broader obesity strategies.
Main Methods:
- 25 semi-structured interviews with GPs across England.
- Purposive sampling to ensure diverse geographical and socioeconomic representation.
- Thematic analysis of interview data collected between April-July 2024.
Main Results:
- GPs generally hold positive views on implementing GLP-1RAs for weight management.
- Concerns exist regarding resource limitations and managing patient requests for prescriptions or private use.
- Worries were raised about GLP-1RAs potentially oversimplifying obesity treatment and detracting from broader determinants.
Conclusions:
- GPs see GLP-1RA integration as valuable but require adequate resources for successful implementation.
- Effective integration necessitates GLP-1RAs being part of a comprehensive, holistic obesity management strategy.
- Addressing GP concerns is crucial for strengthening support for GLP-1RA adoption in primary care.
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: Biguanides and Glitazones
Dipeptidyl Peptidase 4 Inhibitors
Obesity
G Protein-coupled Receptors
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...

