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Updated: Sep 16, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Role of non-coding RNA-regulated ferroptosis in colorectal cancer
Yan-Peng Zhao1, Jun-Liang Liu1, Shuai Wang1
1Department of General Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.
Abstract:
The recently discovered type of programmed cell death, termed ferroptosis, characterized by an iron-dependent accumulation of lipid peroxides, has been demonstrated to play a pivotal role in the progress of tumors. The role of non-coding RNAs (ncRNAs) in various malignant tumors has also been gradually elucidated in recent years. Colorectal cancer (CRC) is a malignant tumor with a high prevalence and mortality rate worldwide. Many recent studies have demonstrated that the effects of ncRNAs on CRC progression may be mediated by their regulation of ferroptosis. This review first outlines the fundamental mechanisms of ferroptosis and the role of ncRNAs in ferroptosis, and then we summarize the role of ferroptosis in CRC. We then focused on summarizing the effect of ncRNAs regulating ferroptosis in CRC and the recent progress of ferroptosis-related ncRNAs as prognostic biomarkers in CRC patients. This review will help to deepen our understanding of the ncRNA-ferroptosis-CRC axis and inform the study of potential therapeutic targets and prognostic markers for CRC patients.
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