Related Experiment Video
Updated: Jun 12, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples
Cheng-Wei Ju1,2,3, Ruitu Lyu1,2, Han Li1,2
1Department of Chemistry, The University of Chicago, Chicago, IL, USA.
Abstract:
Circulating cell-free RNA (cfRNA) in plasma represents a promising avenue for cancer detection. We report low-input multiple methylation sequencing, a method for profiling modification patterns in cfRNA, enabling the detection of diverse transfer RNAs and small noncoding RNAs derived from both the human genome and the microbiome. RNA modification patterns in microbiome-derived cfRNA accurately reflect host microbiota activity and hold potential for the early detection of colorectal cancer.

