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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Related Experiment Video

Updated: Sep 16, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

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Published on: March 2, 2018

[Identification and Control of Collective Neural Dynamics in Autism].

Takamitsu Watanabe¹

¹International Research Centre for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study.

Brain and Nerve = Shinkei Kenkyu No Shinpo

|July 9, 2025

Summary

Autism spectrum disorder involves social and cognitive challenges. This study identifies neural rigidity as a core mechanism and shows it can be reduced with non-invasive neural stimulation, potentially improving core symptoms.

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Area of Science:

Neuroscience
Developmental Psychology
Biomedical Engineering

Context:

Autism spectrum disorder (ASD) presents with core challenges in socio-communicative abilities and cognitive flexibility.
Neural rigidity has been proposed as a potential underlying neural mechanism for these diverse symptoms.
Understanding the neural underpinnings of ASD is crucial for developing effective interventions.

Purpose:

To investigate the role of neural rigidity as a unifying neural mechanism in autism spectrum disorder.
To explore the potential of non-invasive neural stimulation to alleviate neural rigidity.
To assess the impact of mitigating neural rigidity on core autistic symptoms.

Summary:

This research identifies neural rigidity as a central neural mechanism contributing to both social and non-social symptoms in autism spectrum disorder.
Findings demonstrate that a unique closed-loop non-invasive neural stimulation system can effectively alleviate neural rigidity.
The study observed a mitigation of core autistic symptoms following the reduction of neural rigidity.

Impact:

Provides a novel neural mechanism (rigidity) linking diverse autism symptoms.
Demonstrates the therapeutic potential of targeted non-invasive neural stimulation for ASD.
Opens new avenues for developing personalized, mechanism-based interventions for autism spectrum disorder.