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Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools
Published on: June 20, 2020
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Development and validation of the Pediatrics Functional Living Index-Emesis scale
Lili Han1, Jun Deng2, Yuyun Yang2
1Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.
Frontiers in Oncology
|July 9, 2025
Summary
A new tool, the Pediatrics Functional Living Index-Emesis (PFLIE), effectively measures chemotherapy-induced nausea and vomiting (CINV) in children. This validated patient-reported outcome measure (PROM) aids in improving pediatric cancer patients' quality of life.
Area of Science:
- Oncology
- Patient-Reported Outcomes
- Pediatric Health
Background:
- Chemotherapy-induced nausea and vomiting (CINV) significantly impacts cancer patients' quality of life (QoL).
- Existing assessment tools lack specificity for pediatric cancer patients.
- There is a critical need for a validated measure to assess CINV's QoL impact in children.
Purpose of the Study:
- To develop and validate the Pediatrics Functional Living Index-Emesis (PFLIE) as a patient-reported outcome measure (PROM).
- To assess the impact of CINV on the QoL of pediatric cancer patients.
Main Methods:
- The PFLIE underwent two rounds of Delphi expert consultation for content validity.
- Reliability, structural validity, and concurrent validity were assessed via a survey of 90 pediatric cancer patients.
- The study adhered to the Declaration of Helsinki and received IRB approval.
Main Results:
- The PFLIE demonstrated high internal consistency (Cronbach's alpha 0.964) and strong validity.
- Content validity index (CVI) for nausea and vomiting domains was 0.933.
- Item-domain correlations supported acceptable construct and concurrent validity.
Conclusions:
- The Chinese version of the PFLIE is a reliable and valid tool for assessing CINV's impact on pediatric cancer patients' QoL.
- The PFLIE can assist healthcare providers in managing CINV and improving patient QoL.
- This tool is particularly valuable in low- and middle-income countries (LMICs) for enhancing pediatric cancer care.
