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Related Experiment Video

Updated: Sep 16, 2025

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Comparison of Subconjunctival Triamcinolone with Topical Prednisolone for Routine Anti-Inflammatory Prophylaxis in

Renato Papa-Vettorazzi1, Neal H Shorstein2, Brittany Peterson3

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Summary

This pilot study compares subconjunctival triamcinolone acetonide injections to topical drops for preventing inflammation after manual small incision cataract surgery (MSICS). The injection method appears safe and effective for managing postoperative inflammation in MSICS.

Keywords:
cystoid macular edemadropfree cataract surgeryintraocular pressure riserebound iritistriamcinolone acetonide injection

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Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Clinical Trials

Background:

  • Cataract surgery is a common global procedure.
  • Current postoperative care involves topical drops, which can be challenging for patient adherence.
  • Injected medications offer a potential alternative for prophylaxis against endophthalmitis and inflammation.

Purpose of the Study:

  • To evaluate the safety and efficacy of subconjunctival triamcinolone acetonide (TA) injection versus standard topical prednisolone acetate (PA) drops.
  • To assess the safety of injection techniques in manual small incision surgery (MSICS).

Main Methods:

  • A pilot randomized controlled trial involving 100 patients undergoing uncomplicated MSICS.
  • Group 1: Standard postoperative topical prednisolone acetate (PA) 1% drops.
  • Group 2: Single subconjunctival injection of triamcinolone acetonide (TA). Both groups received intracameral moxifloxacin. Outcomes measured included intraocular pressure (IOP), visual acuity, and inflammation.

Main Results:

  • The study primarily assessed intraocular pressure (IOP) as a safety measure.
  • Secondary outcomes included corrected distance visual acuity (CDVA), anterior chamber inflammation, and corneal/macular edema.
  • Data analysis focused on comparing the injection group with the topical drop group.

Conclusions:

  • This pilot study aims to determine if subconjunctival TA injections are a safe and effective alternative to topical drops for managing inflammation after MSICS.
  • Further research will elucidate the comparative benefits and risks in a larger cohort.