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Optic Nerve Head Microvascular Changes Associated with Intracranial Aneurysms
Tuna Celik Buyuktepe1, Murat Buyuktepe2, Pinar Bingol Kiziltunc3
1Department of Ophthalmology, Unye State Hospital, Ordu, Türkiye.
Beyoglu Eye Journal
|July 9, 2025
Summary
Intracranial saccular aneurysms and related treatments did not significantly alter optic nerve head microvasculature. Further research with larger cohorts is needed to confirm these findings in specific anatomical locations.
Area of Science:
- Ophthalmology
- Neurology
- Vascular Biology
Background:
- Intracranial saccular aneurysms can affect neurological function.
- Optic nerve head (ONH) microvascular changes may occur secondary to these aneurysms.
- Optic coherence tomography angiography (OCTA) is a key tool for evaluating microvasculature.
Purpose of the Study:
- To investigate microvascular alterations in the optic nerve head (ONH) in patients with intracranial saccular aneurysms.
- To compare ONH microvascular indices between patients and healthy controls.
- To assess changes in unilateral cases compared to contralateral eyes.
Main Methods:
- A prospective study comparing 16 patients with intracranial aneurysms (Group 1) to 16 age-matched controls (Group 2).
- Ophthalmic evaluations included visual acuity, refraction, and cranial nerve function.
- OCTA was used to assess ONH microvascular density and thickness.
Main Results:
- No significant differences in ONH microvascular indices were found between patients and controls (p>0.05).
- Slight, statistically insignificant decreases in vascular density and thickness were noted in the nasal inferior sector of the ONH in patients.
- Microvascular indices showed statistically insignificant increases in the ipsilateral eye compared to the contralateral eye in unilateral aneurysm cases.
Conclusions:
- Intracranial saccular aneurysms, subarachnoid hemorrhage, or neurosurgical intervention did not lead to significant ONH microvascular changes.
- Larger studies are required to confirm these findings and explore anatomical variations.
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