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Related Experiment Video

Updated: Sep 16, 2025

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

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Measuring Regulatory Network Inheritance in Dividing Yeast Cells Using Ordinary Differential Equations.

Wenbin Wu¹, Taylor Kennedy², Orlando Arguello-Miranda²

¹Department of Statistics, University of Washington.

Biorxiv : the Preprint Server for Biology

|July 9, 2025

Summary

This summary is machine-generated.

We developed ODEinherit, a new method using ordinary differential equations (ODEs) to quantify how much protein regulation is inherited during cell division. This framework reveals significant variation in inheritance across cell generations.

Keywords:

Asymmetric cell division Cellular dynamics Live-cell imaging Ordinary differential equation Protein regulatory network

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Last Updated: Sep 16, 2025

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ODELAY: A Large-scale Method for Multi-parameter Quantification of Yeast Growth

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Area of Science:

Cell biology
Systems biology
Quantitative biology

Background:

Inheritance of protein regulation during asymmetric cell division is complex and lacks formal mathematical definition.
Understanding this inheritance is crucial for predicting cell fate and responses to stress.

Purpose of the Study:

To introduce ODEinherit, a novel statistical framework for quantifying protein regulatory network inheritance during cell division.
To address the challenge of measuring how much of a mother cell's regulatory network is passed to its daughters.

Main Methods:

Utilizing ordinary differential equations (ODEs) to estimate cell-specific regulatory networks.
Incorporating adjustments for non-oscillatory trajectories and network density.
Quantifying inheritance by assessing a mother's network's explanatory power for daughter cell trajectories.

Main Results:

ODEinherit accurately quantifies inheritance, with precise measurement depending on network density adjustments.
Benchmarked on simulated data and applied to live-cell microscopy of 85 dividing S. cerevisiae cells.
Revealed substantial heterogeneity in inheritance rates among mother-daughter cell pairs.

Conclusions:

ODEinherit provides a robust method for quantifying protein regulatory inheritance.
The observed heterogeneity has implications for understanding cellular stress response and cell-fate prediction.
This framework opens new avenues for studying inheritance across cell generations.