Related Experiment Video

Updated: Sep 16, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Association between renal function and arterial stiffness among women with systemic lupus erythematosus or

Ewa Pędzich1, Adrian Bednarek1, Dominika Klimczak-Tomaniak2,3

  • 1First Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.

Cardiology Journal
|July 9, 2025
PubMed

Insights

In women with systemic lupus erythematosus (SLE) or antiphospholipid syndrome (APS), elevated urea and uric acid levels correlate with increased arterial stiffness. These findings highlight potential links between renal function markers and cardiovascular risk in these patient populations.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Rheumatology

Background:

  • Patients with SLE or APS face heightened risks of atherosclerosis and major adverse cardiac events.
  • The underlying mechanisms linking SLE/APS to cardiovascular complications remain incompletely understood.
  • While renal impairment is recognized in SLE/APS, data on arterial remodeling markers (AI@75, PWV) and renal function are scarce in affected women.

Purpose of the Study:

  • To investigate the association between arterial remodeling parameters (AI@75, PWV) and laboratory markers of renal function in women with SLE and/or APS.
  • To explore the relationship between non-invasive measures of arterial stiffness and renal function tests in this specific patient cohort.

Main Methods:

  • Prospective, cross-sectional study involving women diagnosed with SLE and/or APS.
  • Carotid-femoral pulse wave velocity (PWV) and augmentation index normalized to 75 bpm (AI@75) were measured using pulse wave analysis.
  • Laboratory assessments of renal function were conducted concurrently.

Main Results:

  • Urea levels showed a significant correlation with both AI@75 (rho = 0.362, p = 0.006) and PWV (rho = 0.487, p = 0.006).
  • Adjusted analyses revealed associations between urea, uric acid, creatinine, and estimated glomerular filtration rate (eGFR) with AI@75.
  • Specifically, higher urea, uric acid, and creatinine, and lower eGFR were linked to increased AI@75.

Conclusions:

  • Urea and uric acid levels are associated with increased arterial stiffness (measured by PWV and AI@75) in women with SLE or APS.
  • These findings suggest a connection between renal function markers and arterial stiffness in women with SLE or APS, even with normal or mildly impaired kidney function.
Abstract

Keywords:
antiphospholipid syndromearterial stiffnesspulse wave velocitysystemic lupus erythematosusureauric acid

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.7K

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
165
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
38
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
35
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
31
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
104
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
24