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Updated: Sep 16, 2025
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Impact of morphological variations on preoperative and postoperative central corneal thickness in congenital
Suzu Deie1, Yoshiaki Kiuchi2, Kaori Komatsu2
1Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan. syoshito@hiroshima-u.ac.jp.
Purpose:
Central corneal thickness (CCT) has been reported to be thicker in aphakic and pseudophakic eyes after congenital cataract surgery. We aimed to investigate the factors influencing preoperative CCT and changes in CCT after cataract surgery.
Methods:
We included 62 eyes of 39 patients with congenital cataracts who underwent cataract surgery at Hiroshima University between February 2006 and July 2022. Pre- and postoperative CCT were measured using a noncontact specular microscope or ultrasound pachymeter. Cataracts were categorized into five morphologies: anterior, posterior, nuclear, total, and others (aculeiform, calcific, cortical, lamellar, pulverulent, and membranous). Statistical analyses were conducted using JMP software, with significance set at P < 0.05.
Results:
No significant differences in CCT were observed between bilateral and unilateral cataracts or between operated and fellow eyes with unilateral cataracts. However, when cataracts were categorized according to morphology into five categories, namely, anterior cataract, posterior cataract, nuclear cataract, total cataract, and others, the others group exhibited significantly thicker CCT than did the control group (566.6 ± 76.2 µm vs. 525.9 ± 31.2 µm, P = 0.032). Preoperative CCT decreased inversely with age. Postoperative CCT increased significantly compared with preoperative measurements (544.0 ± 35.9 µm vs. 534.5 ± 28.4 µm, P = 0.021).
Conclusion:
This study highlights that congenital cataract of specific morphologies, particularly those classified in the others group, affect CCT. Preoperative CCT decreased with age. The increase in postoperative CCT suggests that surgical intervention can affect corneal thickness.
