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Updated: May 3, 2026

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Using Luciferase to Image Bacterial Infections in Mice
Published on: February 18, 2011
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Autonomous bioluminescence emission from transgenic mice
Kamila A Kiszka1, Christian Dullin2,3,4, Heinz Steffens1
1Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Science Advances
|July 9, 2025
Abstract:
The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here, we report the generation of an autobioluminescent transgenic mouse line constitutively expressing the genes of the bacterial bioluminescence system, enabling substrate-free in vivo luminescence imaging of a living mammal.

