Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

192
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
192
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

999
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
999
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

127
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
127
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

152
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
152
Schizophrenia01:17

Schizophrenia

234
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
234
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

344
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
344

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis.

Schizophrenia bulletin open·2026
Same author

Converting negative symptom dimension scores across SANS and PANSS.

Schizophrenia research·2026
Same author

Association of Fetal Gene Regulatory Gene Deletions With Poor Cognition in Schizophrenia and Community-Based Samples.

The American journal of psychiatry·2026
Same author

Exploring Group Differences in Attenuated Symptoms and Functioning Between Clinical High-Risk Individuals With and Without Posttraumatic Stress Disorder.

Early intervention in psychiatry·2026
Same author

Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis.

JAMA psychiatry·2026
Same author

Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.

Schizophrenia bulletin·2026

Related Experiment Video

Updated: Sep 16, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.7K

Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms

Ricardo E Carrión1, Majnu John2, Sarah Dorvil3

  • 1Northwell, New Hyde Park, New York; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York; Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.

Biological Psychiatry
|July 9, 2025
PubMed
Summary

Difficulties in social functioning for adolescents at clinical high-risk for psychosis (CHR-P) are linked to early auditory processing deficits, primarily through impaired processing speed, not social cognition. These findings highlight potential early intervention targets.

Keywords:
Clinical high risk for developing psychosisEvent-related potentialsMismatch negativityProcessing speedSocial cognitionStructural equation modeling (SEM)

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.0K
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.0K

Related Experiment Videos

Last Updated: Sep 16, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.7K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.0K
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.0K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Social functioning deficits in adolescents and young adults at clinical high-risk for psychosis (CHR-P) are significant predictors of psychosis onset.
  • Previous research in schizophrenia suggests links between auditory processing (Mismatch Negativity - MMN), neurocognition, social cognition, negative symptoms, and social functioning.
  • The precise pathways and determinants of social functioning impairments in CHR-P youth before illness onset remain unclear.

Purpose of the Study:

  • To investigate the interrelationships between early auditory processing, neurocognition, social cognition, negative symptoms, and social functioning in CHR-P youth.
  • To identify specific determinants of poor social functioning in CHR-P individuals using structural equation modeling (SEM).

Main Methods:

  • Utilized data from 518 CHR-P individuals from the North American Prodrome Longitudinal Study (NAPLS2).
  • Employed structural equation modeling (SEM) to examine pathways from Mismatch Negativity (MMN) to social functioning.
  • Included processing speed and negative symptoms as intervening variables, alongside social cognition.

Main Results:

  • A structural equation model indicated that early auditory processing (MMN) directly influenced processing speed.
  • Processing speed and negative symptoms were found to have direct effects on social functioning.
  • The direct impact of social cognition on social functioning was not statistically significant in the model.

Conclusions:

  • Neurophysiological deficits, specifically in early auditory processing, are associated with social functioning impairments in CHR-P youth.
  • Processing speed deficits fully mediate the relationship between early auditory processing and social functioning.
  • Findings suggest that interventions targeting early information processing deficits may improve social trajectories and potentially delay or prevent psychosis onset in at-risk youth.