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Related Experiment Video

Updated: Sep 16, 2025

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
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A Novel Quantitative Hemodynamic Evaluation Method of Laser Therapy for Scars Based on Diffuse Correlation

Zhe Li1,2, Yongjian Liu1,2, Peng Tian3

  • 1School of Information Science and Technology, Beijing Key Laboratory of Computational Intelligence and Intelligent System, Beijing University of Technology, Beijing, China.

Journal of Biophotonics
|July 10, 2025
PubMed
Summary

Diffuse Correlation Spectroscopy (DCS) quantitatively evaluates laser therapy for scars by monitoring microvascular blood flow. This method reliably assesses treatment effects, aiding clinicians in understanding scar hemodynamics.

Keywords:
diffuse correlation spectroscopylaser therapymicrovascular blood flowquantitative hemodynamic evaluationscar

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Area of Science:

  • Biomedical Optics
  • Medical Devices
  • Laser Therapy

Background:

  • Scarring affects microvascular function.
  • Quantitative hemodynamic assessment is crucial for evaluating scar treatments.
  • Laser therapy is a common modality for scar revision.

Purpose of the Study:

  • To propose and validate a quantitative hemodynamic evaluation method for scar laser therapy using Diffuse Correlation Spectroscopy (DCS).
  • To assess the feasibility of DCS in monitoring microvascular blood flow changes post-laser treatment in scars.

Main Methods:

  • Development of a custom-built DCS device for in vivo measurements.
  • Monitoring of microvascular blood flow (BF) and power spectral density (PSD) before and after laser therapy in six participants.
  • Application of two laser therapy types: one inducing vasoconstriction, the other vasodilation.

Main Results:

  • Vasoconstriction laser therapy significantly reduced scar BF by 43.27% and PSD by 72%.
  • Vasodilation laser therapy significantly increased scar BF by 338.73% and PSD by 917%.
  • DCS demonstrated reliable quantitative evaluation of laser therapy effects on scar hemodynamics.

Conclusions:

  • DCS provides a reliable method for quantitative hemodynamic evaluation of scar laser therapy.
  • The findings support the use of DCS to guide and optimize scar treatment strategies.
  • DCS can assist clinicians in understanding and managing microvascular changes in scars.